Epithelial-mesenchymal transition and gastric cancer
Author(s): LIU Li-min, LI Ji-kun
Pages: 924-926
Year: 2013 Issue: 12
Journal: Journal of International Oncology
Keyword: Stomach neoplasms; Signal transduction; Neoplasm metastasis; Epithelial-mesenchymal transition;
Abstract: Epithelial-mesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype.Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells.The process of EMT involves a number of signal transduction pathways,and is related to microRNAs,Helicobacter pylori,transcription factors and so on.EMT is expected to be a novel therapeutic target of gastric cancer.
Pages: 924-926
Year: 2013 Issue: 12
Journal: Journal of International Oncology
Keyword: Stomach neoplasms; Signal transduction; Neoplasm metastasis; Epithelial-mesenchymal transition;
Abstract: Epithelial-mesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype.Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells.The process of EMT involves a number of signal transduction pathways,and is related to microRNAs,Helicobacter pylori,transcription factors and so on.EMT is expected to be a novel therapeutic target of gastric cancer.
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