Treatment of Canine Osteonecrosis of Femoral Head with Bone Impaction Grafting Soaked in Tanshi-none Ⅱ-a
Author(s): LI Xiaoming, GUO Donghui, SHI Guojun, LI Ruiliang, ZHANG Hongxiang, SU Changsheng, SHEN Runbin, WANG Hongyu, LI Yunmei, YUAN Fulu, HAN Guangpu
Pages: 664-666
Year: 2013 Issue: 6
Journal: Chinese Journal of Surgery of Integrated Traditional and Western Medicine
Keyword: Osteonecrosis; tanshinone; core decompression; graft; dog;
Abstract: Objective: To analyze the efficiency of bone impaction grafting with Tanshinone Ⅱ-a in the treatment of Canine osteonecrosis of the femoral head. Methods Twelve canine models were made with femo-ral head avascular necrosis induced by liquid nitrogen frozen, and were randomly divided into two groups. In the experimental group cancellous bone soaked in Tanshi-none Ⅱ-a was implanted into the femoral head, and in the control group cancellous bone was implanted only. X-ray, specimen histology and scanning elec-tron microscopy were done postoperatively Results In the experimental group, the (bone mass density BMD) of the femoral head was higher. Light transmission area was smaller than the control group; bone histology showed in the experimental group, the number of empty lacunae and fat cell diameter was significantly improved as com-pared with the control group (P<0.05). After twelve weeks, scanning electron microscopy showed that cartilage surface was very similar to normal hyaline cartilage and active proli-feration of osteoblasts, mature osteocytes were shown into a round, clear membrane. Conclusion Tanshinone Ⅱ-a can improve the blood supply of the femoral head and promote the absorption of necrotic bone repair and reconstruction.
Pages: 664-666
Year: 2013 Issue: 6
Journal: Chinese Journal of Surgery of Integrated Traditional and Western Medicine
Keyword: Osteonecrosis; tanshinone; core decompression; graft; dog;
Abstract: Objective: To analyze the efficiency of bone impaction grafting with Tanshinone Ⅱ-a in the treatment of Canine osteonecrosis of the femoral head. Methods Twelve canine models were made with femo-ral head avascular necrosis induced by liquid nitrogen frozen, and were randomly divided into two groups. In the experimental group cancellous bone soaked in Tanshi-none Ⅱ-a was implanted into the femoral head, and in the control group cancellous bone was implanted only. X-ray, specimen histology and scanning elec-tron microscopy were done postoperatively Results In the experimental group, the (bone mass density BMD) of the femoral head was higher. Light transmission area was smaller than the control group; bone histology showed in the experimental group, the number of empty lacunae and fat cell diameter was significantly improved as com-pared with the control group (P<0.05). After twelve weeks, scanning electron microscopy showed that cartilage surface was very similar to normal hyaline cartilage and active proli-feration of osteoblasts, mature osteocytes were shown into a round, clear membrane. Conclusion Tanshinone Ⅱ-a can improve the blood supply of the femoral head and promote the absorption of necrotic bone repair and reconstruction.
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