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Global Stability in a Mo del for CTL Resp onse to HTLV-I Infection
Author(s): 
Pages: 618-624
Year: Issue:  4
Journal: Chinese Quarterly Journal of Mathematics

Keyword:  CTL responseHTLV-I infectionglobal stabilityLyapunov function;
Abstract: In this paper, a mathematical model for HTLV-I infection of CD4+ T cells that incorporates the CD8+ cytotoxic T-cell(CTL) response is studied. We establish two threshold parameters R0 and R1, the basic reproduction numbers for viral persistence and for CTL response, respectively. We also show that the parameter R1 can be used to distinguish asymptomatic carriers from HAM/TSP patients and as an important control parameter for preventing the development of HAM/TSP.
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