Effect of Suanzhiqing Capsule on Renal Function and TNF-αlevel in Nephropathy Rats with Uric Acid
Author(s): Zhang Yuan, Wen Shaodun
Pages: 75-77,80
Year: 2014 Issue: 1
Journal: World Chinese Medicine
Keyword: Suanzhiqing capsule; Uric acid nephropathy; S Renal function; Tumor necrosis factor alpha ( TNF-α);
Abstract: Objective:To observe the effect and explore the mechanism of Suanzhiqing capsule on renal function and TNF -αlevel in Ne-phropathy Rats with Uric Acid .Methods: Male SD rats were divided into five groups including normal group , model group , sodium chloride group , suanzhiqing capsule treatment group , and allopurinol treatment group .Nephropathy rat with uric acid were established by giving adenine and ethambuto .Then model rats were administered intragastrically with sodium chloride , suanzhiqing capsule , or allo-purinol for three weeks.The blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA) in blood and tumor necrosis factor alpha (TNF-α) in renal tissue were determined.Results:(1) Compared with the normal group, the levels of BUN.Cr, and UA in blood in model group significantly increased (P<0.05).(2) Compared with the sodium chloride group , the levels of BUN, and UA in blood in suanzhiqing capsule treatment group and allopurinol treatment group significantly decreased (P<0.05).Although the levels of Cr in al-lopurinol treated group decreased , only in suanzhiqing capsule treated group were significantly .(3)Comparing the levels of BUN.Cr, and UA in suanzhiqing capsule treatment group with those in allopurinol treatment group , there was no significant difference between the two groups (P>0.05).(4) The optical density value of TNF-αin renal tissue of the sodium chloride group was significantly higher than that in normal group(P<0.05).The optical density value of TNF-αin renal tissue of suanzhiqing capsule treatment group and allopurinol treatment group were significantly lower than that in sodium chloride group (P<0.05).(5) Compared with the model group, uratic crystallization and inflammatory cell infiltration were significantly reduced , and tubular expansion had been relieved in both suanzhiqing capsule treatment group and allopurinol treatment group .Conclusion:Suanzhiqing capsule could reduce the levels of BUN .Cr, and UA in blood of nephropathy rats with uric acid , decrease uratic crystallization and inflammatory cell infiltration , and lower TNF-αlevel in re-nal tissue, thus it could have a beneficial effect on uric acid nephropathy rats .
Pages: 75-77,80
Year: 2014 Issue: 1
Journal: World Chinese Medicine
Keyword: Suanzhiqing capsule; Uric acid nephropathy; S Renal function; Tumor necrosis factor alpha ( TNF-α);
Abstract: Objective:To observe the effect and explore the mechanism of Suanzhiqing capsule on renal function and TNF -αlevel in Ne-phropathy Rats with Uric Acid .Methods: Male SD rats were divided into five groups including normal group , model group , sodium chloride group , suanzhiqing capsule treatment group , and allopurinol treatment group .Nephropathy rat with uric acid were established by giving adenine and ethambuto .Then model rats were administered intragastrically with sodium chloride , suanzhiqing capsule , or allo-purinol for three weeks.The blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA) in blood and tumor necrosis factor alpha (TNF-α) in renal tissue were determined.Results:(1) Compared with the normal group, the levels of BUN.Cr, and UA in blood in model group significantly increased (P<0.05).(2) Compared with the sodium chloride group , the levels of BUN, and UA in blood in suanzhiqing capsule treatment group and allopurinol treatment group significantly decreased (P<0.05).Although the levels of Cr in al-lopurinol treated group decreased , only in suanzhiqing capsule treated group were significantly .(3)Comparing the levels of BUN.Cr, and UA in suanzhiqing capsule treatment group with those in allopurinol treatment group , there was no significant difference between the two groups (P>0.05).(4) The optical density value of TNF-αin renal tissue of the sodium chloride group was significantly higher than that in normal group(P<0.05).The optical density value of TNF-αin renal tissue of suanzhiqing capsule treatment group and allopurinol treatment group were significantly lower than that in sodium chloride group (P<0.05).(5) Compared with the model group, uratic crystallization and inflammatory cell infiltration were significantly reduced , and tubular expansion had been relieved in both suanzhiqing capsule treatment group and allopurinol treatment group .Conclusion:Suanzhiqing capsule could reduce the levels of BUN .Cr, and UA in blood of nephropathy rats with uric acid , decrease uratic crystallization and inflammatory cell infiltration , and lower TNF-αlevel in re-nal tissue, thus it could have a beneficial effect on uric acid nephropathy rats .
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