Anesthesia Effects of Dexmedetomidine Combined with Sufentanil on Patients with Aortic Aneurysm Undergoing Endovascular Graft Exclusion
Author(s): LI Ping, MIN Su, WANG Bin, WEI Ke, CHENG Bo, HE Kai-hua, TANG Xiao-ning, The First Affiliated Hospital of Chongqing Medical University
Pages: 3992-3994
Year: 2013 Issue: 42
Journal: China Pharmacy
Keyword: Dexmedetomidine; Sufentanil; Endovascular graft exclusion; Sedation; Analgesia;
Abstract: OBJECTIVE:To observe the safety and effects of dexmedetomidine combined with sufentanil in patients with aortic aneurysm undergoing endovascular graft exclusion. METHODS:60 patients with aortic aneurysm,undergoing selective endovascular graft exclusion in a hospital during Nov. 2011-Mar. 2013 were randomly divided into 2 groups(n=30),i.e. tramadol combined with droperidol group(group C)and dexmedetomidine combined with sulfentanyl group(group D). All patients underwent surgery under local anesthesia. Group D was given intravenous pumped infusion of dexmedetomidine 0.5 μg/kg(10 min at an even speed)before incision,and then maintained at 0.3-0.7 μg(/kg· h);it was also given intravenous injection of sufentanil 0.15-0.2 μg/ kg before incision and exclusion. Group C was given tramadol 100 mg and Droperidol injection 5 mg dissolved in isometric normal saline 15 min before incision,and received isometric normal saline before incision and exclusion. At the time points of entering operation room(T0),1 min(T1),5 min(T2),15 min(T3)after pumped infusion,before exclusion(T4)and 1 min(T5),5 min(T6)after exclusion,the BP,HR,RR,SpO2,Narcotrend index and adverse events such as respiratory depression,bradycardia,hypertension,hypotension,nausea and vomiting and treatments were monitored and recorded. The satisfaction degree of patients and surgeons were followed up. RESULTS:Compared with group C,SBP,DBP and Narcotrend index were decreased at T4-T6 and HR was decreased at T3-T6;the incidence of bradycardia,antihypertensives use and satisfaction degree of patients and surgeons were all higher in group D(P<0.05). Compared with T0,Narcotred index of group C was decreased at T3;SBP and DBP of group D were decreased at T4-T6,and HR and Narcotrend index were decreased at T3-T6(P<0.05). CONCLUSIONS:Dexmedetomidine combined with sufentanil can be safely and effectively used in endovascular graft exclusion of aortic aneurysm patients under local anesthesia,and meet the demand of intraoperative sedation and analgesia. Both patients and surgeons have feeling of satisfaction.
Pages: 3992-3994
Year: 2013 Issue: 42
Journal: China Pharmacy
Keyword: Dexmedetomidine; Sufentanil; Endovascular graft exclusion; Sedation; Analgesia;
Abstract: OBJECTIVE:To observe the safety and effects of dexmedetomidine combined with sufentanil in patients with aortic aneurysm undergoing endovascular graft exclusion. METHODS:60 patients with aortic aneurysm,undergoing selective endovascular graft exclusion in a hospital during Nov. 2011-Mar. 2013 were randomly divided into 2 groups(n=30),i.e. tramadol combined with droperidol group(group C)and dexmedetomidine combined with sulfentanyl group(group D). All patients underwent surgery under local anesthesia. Group D was given intravenous pumped infusion of dexmedetomidine 0.5 μg/kg(10 min at an even speed)before incision,and then maintained at 0.3-0.7 μg(/kg· h);it was also given intravenous injection of sufentanil 0.15-0.2 μg/ kg before incision and exclusion. Group C was given tramadol 100 mg and Droperidol injection 5 mg dissolved in isometric normal saline 15 min before incision,and received isometric normal saline before incision and exclusion. At the time points of entering operation room(T0),1 min(T1),5 min(T2),15 min(T3)after pumped infusion,before exclusion(T4)and 1 min(T5),5 min(T6)after exclusion,the BP,HR,RR,SpO2,Narcotrend index and adverse events such as respiratory depression,bradycardia,hypertension,hypotension,nausea and vomiting and treatments were monitored and recorded. The satisfaction degree of patients and surgeons were followed up. RESULTS:Compared with group C,SBP,DBP and Narcotrend index were decreased at T4-T6 and HR was decreased at T3-T6;the incidence of bradycardia,antihypertensives use and satisfaction degree of patients and surgeons were all higher in group D(P<0.05). Compared with T0,Narcotred index of group C was decreased at T3;SBP and DBP of group D were decreased at T4-T6,and HR and Narcotrend index were decreased at T3-T6(P<0.05). CONCLUSIONS:Dexmedetomidine combined with sufentanil can be safely and effectively used in endovascular graft exclusion of aortic aneurysm patients under local anesthesia,and meet the demand of intraoperative sedation and analgesia. Both patients and surgeons have feeling of satisfaction.
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