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bai xi bao jie su -10 zai sle huan zhe wai zhou xue de guo du biao da
Author(s): 
Pages: 950-951
Year: Issue:  10
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  红斑狼疮系统性白细胞介素10;
Abstract: 目的:检测白细胞介素-10(IL-10)在系统性红斑狼疮(SLE)患者外周血中的表达情况并探讨其临床意义.方法:血清和外周血单个核细胞(PBMC)IL-10含量测定采用ELISA,IL-10mRNA测定采用RT-PCR.结果:(1)活动期和缓解期SLE患者血清IL-10水平和PBMC内IL-10含量均显著高于对照组,活动期显著高于缓解期(均P<0.05);(2)活动期和缓解期SLE患者PBMCIL-10mRNA表达均显著高于正常对照组,活动期显著高于缓解期(均P<0.05);(3)IL-10mRNA表达与血清IL-10水平、PBMCIL-10含量呈正相关关系(r值分别为0.524和0.637,P值分别为0.031和0.018);(4)SLE患者血清IL-10水平、PBMCIL-10含量及IL-10mRNA表达与累积分数SLEDAI均呈正相关关系(r值分别为0.652,0.736,0.514;P值分别为0.022,0.001,0.047),亦均与抗dsDNA抗体滴度呈正相关关系(r值分别为0.513,0.621,0.508;P值分别为0.034,0.025,0.039).结论:SLE患者外周血中IL-10呈高表达状态,参与了SLE的发病机制,且与SLE的病情活动有关.
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