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Issue:
Vitamin D and chronic kindey disease
Author(s):
ZHANG Yuling
Pages:
566
-
570
Year:
2013
Issue:
6
Journal:
Chinese Journal of Nephrology Dialysis & Transplantation
Keyword:
chronic kindey disease
;
vitamin D
;
Abstract:
大多数慢性肾脏病(CKD)患者存在维生素D不足或缺乏.维生素D缺乏不仅导致钙磷代谢紊乱及骨矿化障碍,而且加速肾脏疾病的进展.大量临床研究证实使用活性维生素D或其类似物治疗可减少尿蛋白,延缓肾功能恶化.维生素D可能通过直接保护足细胞减少蛋白尿、抑制肾素-血管紧张素-醛固酮系统、调节免疫、抗炎作用、缓解胰岛素抵抗等诸多途径达到保护肾脏的作用.
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