Author(s): DAI Enlai, ZHAO Jianxiong, ZHU Yuzhen, ZHANG Yuhong, WANG Xuexi
Pages: 760-762
Year: 2001 Issue:  10
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
Keyword:  扶正抑瘤汤; 肿瘤细胞周期; 端粒酶;
Abstract: 目的:探讨扶正抑瘤汤抗肿瘤的作用机理.方法:用S180瘤株接种昆明种小鼠,造成S180实体瘤模型,扶正抑瘤汤等中药灌胃治疗,用流式细胞仪分析实体瘤的细胞周期;用端粒酶试剂盒检测端粒酶活性.结果:各治疗组肿瘤细胞G0/1期比率升高,S期比率下降,端粒酶活性被抑制,与生理盐水(荷瘤)组相比,差异有显著性(P＜0.001).结论:扶正抑瘤汤能阻滞肿瘤细胞增殖的进程,阻抑肿瘤细胞DNA的合成和复制,而端粒酶活性被抑制是影响肿瘤细胞增殖周期进程的机理之一.