Author(s): LUO, Zaigang, ZENG, Chengchu, YANG, Daoshan, HUANG, Yali, WANG, Fang, DU, Hongguang, HU, Liming
Pages: 1333-1338
Year: 2009 Issue:  7
Journal: Chinese Journal of Chemistry
Keyword:  dipeptide derivative; electrospray ionization mass spectrometry (ESI-MS); fragmentation pathway;
Abstract: Based on the structure of the HIV integrase core domain, dipeptide derivatives, as a type of HIV integrase in- hibitor, were synthesized, and their fragmentation pathways were investigated by electrospray ionization mass spec- trometry (ESI-MSN) in conjunction with tandem mass spectrometry (MS/MS). In order to better understand the fragmentation pathways, the MS2 and MS3 spectra of the title compound were obtained. The main fragmentation pathways occur by the cleavage of the C-CO bonds between N-(benzothiazol-2-yl)aminocarbonyl and methylene, NH-CO bonds between the NH groups and carbonyl groups. Electrospray ionization was proven to be a good method for the structural characterization and identification of this kind of compound.