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fib d-dimer jian ce zai ping jia fei ban mo xing fang chan huan zhe xue shuan shuan sai wei xian zhong de jia zhi
Author(s): 
Pages: 1196-1197
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  非瓣膜性房颤纤维蛋白原D-二聚体血栓栓塞;
Abstract: 目的通过对血浆纤维蛋白原(FIB)、D-二聚体(D-dimer)的检测,探讨二者在评价非瓣膜性房颤患者血栓栓塞危险中的价值。方法选择非瓣膜性房颤患者58例,按照CHADS2评分将病例分为3组,0分组为低危组14例,1分~2分组为中危组21例,>2分组为高危组23例。采集空腹静脉血4mL,采用凝固法测定FIB,采用双抗体ELISA吸附法测定D-dimer。结果房颤组FIB、D-dimer的值均较对照组高,FIB(4.71g/L±0.55g/L vs 2.85g/L±0.28g/L,P<0.05),D-dimer(374.60ng/mL±63.48ng/mL vs 84.93ng/mL±27.44ng/mL,P<0.05)。CHADS2评分中危组FIB的值较低危组的高,分别为(4.63g/L±0.38g/L vs 3.27g/L±0.46g/L,P<0.05),高危组FIB的值较中危组的高,分别为(5.36g/L±0.51g/L vs 4.63g/L±0.38g/L,P<0.05);采用Spearman相关性分析,FIB值与低危组无相关性,而FIB值与中危、高位组呈正相关。CHADS2评分D-dimer中危组的值较低危组的高,分别为(263.72ng/mL±45.27ng/mL vs 140.35ng/mL±31.63ng/mL,P<0.05),高危组D-dimer的值较中危组的高,分别为(434.28ng/mL±57.68ng/mL vs 263.72ng/mL±45.27ng/mL,P<0.05);采用Spearman相关性分析,D-dimer的值与低危组无相关性,而D-dimer的值与中危、高危组呈正相关。结论非瓣膜性房颤患者存在血栓前状态;FIB、D-dimer可以作为评价中危、高危非瓣膜性房颤患者血栓栓塞危险的指标。
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