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Effect of Ningxin Lifei Decoction on Plasma Levels of Placenta Growth Factor in Animal Model with Pulmonary Hypertension
Author(s): 
Pages: 1229-1230
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  pulmonary hypertensionmonocrotalineplacenta growth factorNingxin Lifei decoction;
Abstract: Objective To establish a rat model with pulmonary hypertension and observe the intervention effects of Ningxin Lifei decoction(NLD)on pulmonary hypertension and expression of placenta growth fact or.Methods In 30 wistar rats,10were in the n ormal group and 20rats were injected monocrotaline to establish animal model with pulmonary hypertension.The treatment group(n=10)was given NLD by gastric perfusion.The control group(n=10)was given physiological saline.Mean pulmonary arterial pressure and right ventricular end systolic were measured via a catheter after 4weeks.The plasma levels of placenta growth fact or were detected.The rats were killed and right ventricular hypertrophy index were calculated.The pulmonary vascular remodeling and tuba wall thickness of pulmonary vascular diameter<300μm were observed.The tube wall thickness index was calculated.Results The pulmonary artery mean pressure,left ventricular end systolic and right ventricular hypertrophy index in treatment group vere reduced m ore than control group(P<0.05).Similarly,so did f or MT%and the plasma levels of placenta growth fact or.Conclusion NLD was effective to reduce pulmonary arterial pressure and inhibit the pulmonary arterial remodeling.The mechanism might be related with the effect of placenta growth fact or.
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