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Correlation of Serum Cystatin C and Nuclear Factor-κB with Vascular Remodeling in Elderly Patients with Hypertension
Author(s): 
Pages: 1193-1196
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  hypertensionserum cystatin Cnuclear factor-κBrenal functionvascular remodeling;
Abstract: Objective To investigate the c orrelation of serum cystatin C(Cys-C),nuclear fact or-κB(NF-κB)with vascular remodeling in elderly patients with hypertension.Methods The serum concentrations of Cys-C were measured by immunoturbidimetry in 42 cases of elderly hypertension patients with n ormal renal function,48 cases of elderly hypertension patients with abn ormal renal function and 46 cases of n ormal person.NF-κB activation expression rate was detected using immunohistochemical method.Vascular ultrasound was used to detect vascular remodeling.Results The level of Cys-C,NF-κB in patients with hypertension were significantly higher than n ormal control group.The serum concentrations of Cys-C and peripheral blood mononuclear cell NF-κB activation rate were significantly positively c orrelated(r=0.657,P<0.01).Serum level of Cys-C and endogenous creatinine clearance rate had significant negative c orrelation(r=-0.577,P<0.01).There were positive c orrelation among Cys-C,NF-κB levels and vascular remodeling indicat ors,which could be reflected by carotid artery diameter,intima-media thickness and carotid artery plaque sc ore and artery resistance index and pulsatility index.Conclusion Serum Cys-C was the early detection indicat or of kidney injury.The level of serum Cys-C and peripheral blood monocyte NF-κB activation rate were significantly c orrelated.Cys-C possibly through NF-κB participates in the cell signal transduction.Both Cys-C and NF-κB were vascular remodeling indexes in elderly patients with hypertension.
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