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tong guo liang fu he dui da shu xue xi ji yi gong neng de ying xiang
Author(s): 
Pages: 1243-1244
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  学习记忆Morris水迷宫;
Abstract: 目的观察铜负荷饮食对大鼠空间学习记忆行为的影响。方法 40只雄性大鼠适应性喂养1周后,随机分为模型组和空白对照组各20只,模型组予含硫酸铜1g/kg的粉状饲料和含量为0.185%硫酸铜的去离子水喂养,正常对照组喂食普通饲料,8周后采用Morris水迷宫实验测试大鼠学习记忆能力,采用原子吸收法测肝、脑组织铜元素含量。结果 Morris水迷宫实验:模型组大鼠在定位航行试验中平均逃避潜伏期较正常对照组显著延长,空间探索试验中穿越平台次数较正常组明显减少(P<0.01),与正常组比较,模型组大鼠肝、脑组织Cu元素含量明显增加(P<0.01)。结论铜负荷饮食可以引起大鼠的学习记忆障碍。
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