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duan li mei zai fu ke zhong liu zhong de biao da
Author(s): 
Pages: 697-698
Year: Issue:  8
Journal: THE JOURNAL OF PROACTICAL MEDICINE

Keyword:  生殖器肿瘤端粒女(雌)性;
Abstract: 目的∶探讨端粒酶活性在妇科恶性肿瘤中的表达.方法:采用端粒酶重复序列扩增法(TRAP法)对21例患者进行了检测,其中慢性宫颈炎10例,宫颈上皮内瘤样变(CIN)Ⅱ~Ⅲ级2例,子宫颈癌3例,子宫内膜癌3例,内胚窦瘤1例,子宫肌瘤1例,盆腔平滑肌肉瘤1例;所有病例同时行病理石蜡切片检查.结果:恶性肿瘤中端粒酶呈阳性,而良性病变中端粒酶呈阴性.结论:端粒酶的活性与恶性肿瘤的发生和进展有密切相关性,因此端粒酶不仅可能有助于恶性肿瘤的早期诊断,也可能对手术后判断癌细胞侵及范围,以及恶性肿瘤的预后判定有重要的临床意义.
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