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bxi bao xing fei huo qi jin lin ba liu bcl-2 ji yin biao da de lin chuang yi yi
Author(s): 
Pages: 705-706
Year: Issue:  8
Journal: THE JOURNAL OF PROACTICAL MEDICINE

Keyword:  淋巴瘤B细胞 淋巴瘤非霍奇金氏 基因Bcl-2;
Abstract: 目的∶通过检测Bcl-2在B细胞型非霍奇金淋巴瘤细胞中的表达,探讨它在肿瘤恶性程度、疗效及预后判断中的意义.方法:收集病理确诊的初治B细胞型非霍奇金淋巴瘤45例,病理标本均行常规石腊包埋、HE染色和免疫组化LSAB法标记.结果:45例B细胞型非霍奇金淋巴瘤患者中,Bcl-2表达在高度恶性患者中为66.7%,低、中度患者为6.7%.Bcl-2阳性患者初次治疗完全缓解(CR)率为41.7% ,Bcl-2阴性者CR中率为90%,两者比较差异有显著意义(P<0.05).Bcl-2阴性者长期生存率明显高于Bcl-2阳性者(P<0.05).结论:检测Bcl-2在B细胞型非霍奇金淋巴瘤中的表达对肿瘤恶性程度及对预后的判断均有一定意义.
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