Observation of Protective Effects of Shenfu Injection against Myocardial Injury in Septic Patients
Author(s): WU Xi-ping, SHEN Li-juan, ICU, The Affiliated Wuxi Hospital of Nanjing University of TCM
Pages: 3790-3792
Year: 2013 Issue: 40
Journal: China Pharmacy
Keyword: Sepsis; Myocardial injury; CK; CK-MB; cTnT; MDA; SOD; Shenfu injection;
Abstract: OBJECTIVE:To observe the protective effects of Shenfu injection against myocardial injury in septic patients.METHODS:55 patients with sepsis or sepsis shock complicating with myocardial injury were randomly divided into control group(25 cases)and treatment group(30 cases).Both groups were given anti-infective therapy,organs protection,nutritional support and symptomatic treatment.Control group was additionally treated with polarized solution(10% Glucose injection 500 ml + insulin 8 U+10% Potassium chloride injection 10 ml),i.v.,once a day;treatment group was additionally given intravenous dripping of Shenfu injection 100 ml in 5% Glucose solution 250 ml once a day on the basis of the treatment of control group.The course of treatment in two groups was 2 weeks.The levels of CK,CK-MB,cTnT,MDA and SOD of 2 groups were observed 1,5 and 10 days after treatment.Adverse drug reaction was also observed.RESULTS:Compared with a day after treatment,the levels of CK,CK-MB,cTnT and MDA in treatment group were decreased significantly 5 and 10 days after treatment,which were significantly lower than in control group(P<0.05);the level of SOD was increased significantly,and higher than in control group(P<0.05).No adverse drug reaction was found in both groups.CONCLUSIONS:Shenfu injection has anti-oxide free radical effect and anti-lipid peroxidation effect,and relieves myocardial injury of sepsis patients with sound safety to some extent.
Pages: 3790-3792
Year: 2013 Issue: 40
Journal: China Pharmacy
Keyword: Sepsis; Myocardial injury; CK; CK-MB; cTnT; MDA; SOD; Shenfu injection;
Abstract: OBJECTIVE:To observe the protective effects of Shenfu injection against myocardial injury in septic patients.METHODS:55 patients with sepsis or sepsis shock complicating with myocardial injury were randomly divided into control group(25 cases)and treatment group(30 cases).Both groups were given anti-infective therapy,organs protection,nutritional support and symptomatic treatment.Control group was additionally treated with polarized solution(10% Glucose injection 500 ml + insulin 8 U+10% Potassium chloride injection 10 ml),i.v.,once a day;treatment group was additionally given intravenous dripping of Shenfu injection 100 ml in 5% Glucose solution 250 ml once a day on the basis of the treatment of control group.The course of treatment in two groups was 2 weeks.The levels of CK,CK-MB,cTnT,MDA and SOD of 2 groups were observed 1,5 and 10 days after treatment.Adverse drug reaction was also observed.RESULTS:Compared with a day after treatment,the levels of CK,CK-MB,cTnT and MDA in treatment group were decreased significantly 5 and 10 days after treatment,which were significantly lower than in control group(P<0.05);the level of SOD was increased significantly,and higher than in control group(P<0.05).No adverse drug reaction was found in both groups.CONCLUSIONS:Shenfu injection has anti-oxide free radical effect and anti-lipid peroxidation effect,and relieves myocardial injury of sepsis patients with sound safety to some extent.
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