Author(s): ZHENG Xianjun, JIANG Jinyu, KONG Gaoyin, ZHANG Yu
Pages: 1593-1595
Year: 2013 Issue:  8
Journal: Journal of Clinical Research
Keyword:  Pulmonary Ventilation;
Abstract: [Objective]To observe the impact of aerosolized penehyclidine hydrochloride inhalation on in-trapulmonary shunt fraction(Qs/Qt) ,oxygenation index(OI) and blood lactic acid(BLA) during one-lung ven-tilation(OLV) .[Methods]Twenty eight patients with OLV undergoing open chest operation were chosen and randomly divided into penehyclidine hydrochloride group(group P ,aerosolized penehyclidine hydrochloride in-halation during OLV) and control group(group C) .Arterial and mixed venous blood were drawn for blood gas analysis and BLA detection 15min before OLV (T0 ) ,15min(T1 ) and 45min after OLV (T2 ) .Qs/Qt and OI were calculated .[Results]After OLV ,OI in two groups decreased ,but that in group P decreased more slowly than that in group C .Compared with T1 ,OI in group P at T2 rose again .After OLV ,Qs/Qt and BLA in two groups increased ,but that in group P increased more slowly than that in group C .Compared with T1 ,Qs/Qt and OI in group P at T2 declined again .[Conclusion]Aerosolized penehyclidine hydrochloride inhalation during OLV can improve oxygenation and decrease intrapulmonary shunt .