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Recurrence pattern of histological node-negative squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with lymphadenectomy
Author(s): 
Pages: 908-911
Year: Issue:  10
Journal: Chinese Journal of Surgery

Keyword:  Esophagus neoplasmsLymph node dissectionRecurrence and metastasis;
Abstract: Objective To analyze the clinical and pathologic influencing factors of early recurrence in patients with histological node-negative (pN0 stage) esophageal squamous cell carcinoma after radical esophagectomy.Methods A retrospective study on 112 consecutive pN0 stage esophageal squamous cell carcinoma patients who underwent esophagectomy with lymphadenectomy by the same surgical team from January 2004 to December 2010.There were 92 male and 20 female patients,aging from 36 to 80 years with a mean age of 60.3 years.The Cox proportional hazards model was used to determine the independent risk factors for recurrence within 3 years after the operation.Results Recurrence was recognized in 45 patients (40.2%) within 3 years after operation.The median time to tumor recurrence was 17.4 months.Locoregional recurrence was found in 38 patients (33.9%),and hematogenous metastasis in 7 patients (6.3%).Recurrence closely correlated with tumor location,grade of differentiation,pT stage and pathologic stage (x2 =6.380 to 18.837,P < 0.05).The Cox multivariate analysis showed that tumor location (RR =1.092,P =0.049) and pT3-4a stage (RR =3.296,P =0.017) were independent risk factors for postoperative locoregional recurrence.Conclusions The most common recurrence pattern of patients with pN0 esophageal squamous cell carcinoma would develop recurrence within 3 years after operation is locoregional recurrence.Upper/middle thoracic location and pT3-4a stage are independent risk factors for locoregional recurrence of pN0 esophageal squamous cell carcinoma after operation.
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