The clinical characteristics and prognostic analysis of 147 cases of diffuse large B-cell lymphoma
Author(s): ZHAO Qian, FU Wei-jun, ZHANG Chun-yang, DU Juan, XI Hao, HOU Jian
Pages: 737-740
Year: 2013 Issue: 9
Journal: Chinese Journal of Hematology
Keyword: Lymphoma; large cell; diffuse; Hans algorithm; Choi algorithm; Immunohistochemistry; Prognosis;
Abstract: Objective To investigate the relationship between the clinical features,pathogenesis,immunophenotype,different classification models and prognosis in Chinese patients with diffuse large B-cell lymphoma(DLBCL).Methods A total of 147 patients with DLBCL who were treated with CHOP-like or R-CHOP were subjected to analysis.Standard two-step Envision method of immunohistochemical staining was used to assess the expression of CD10,Bcl-6,MUM1,FOXP1,GCET1,CD5,Bcl-2,Ki-67,then according to Hans algorithm,Choi algorithm and Molecular markers,we compared the differences of their prognosies.Results ①)Kaplan-Meier univariate analysis of the clinical data of 147 DLBCL patients found that the 3-year overall survival (OS) rates were better in early stage (P=0.032),low IPI score (P=0.001),less than one extranodal involvement (P=0.014),and complete remission (P ＜ 0.01).The prognosies had no significant differenced in terms of gender,age,LDH,B symptoms and treatment options (P value ＞ 0.05).②For Hans model,GCB group had 42 cases,the ABC group 85 cases; GCB were 47 cases,ABC 80 cases (according to Choi model).Choi model suggested GCB subtype showed much better prognosis than ABC subtype (P=0.047),while Hans model shed no statistically significant difference (P=0.285).③Ki-67 of 75％ was found to significantly discriminate patients with good or bad prognosis.In R-CHOP group at the same time,low Ki-67 (P=0.017) and CD5-negative groups (P=0.012) were better.Cox proportional hazards regression model showed that IPI score (P=0.002) and Ki-67 (P=0.019) were independent adverse prognostic factors.Conclusion The Ann Arbor stage,IPI score,extranodal involvement status and Ki-67 were significantly associated with prognosis.Compared to Hans algorithm,Choi had an advantage to predict the differente prognosis between subtypes,and ABC group had poor outcome.Finally,both Ki-67 and IPI score were independent adverse prognostic factors.
Pages: 737-740
Year: 2013 Issue: 9
Journal: Chinese Journal of Hematology
Keyword: Lymphoma; large cell; diffuse; Hans algorithm; Choi algorithm; Immunohistochemistry; Prognosis;
Abstract: Objective To investigate the relationship between the clinical features,pathogenesis,immunophenotype,different classification models and prognosis in Chinese patients with diffuse large B-cell lymphoma(DLBCL).Methods A total of 147 patients with DLBCL who were treated with CHOP-like or R-CHOP were subjected to analysis.Standard two-step Envision method of immunohistochemical staining was used to assess the expression of CD10,Bcl-6,MUM1,FOXP1,GCET1,CD5,Bcl-2,Ki-67,then according to Hans algorithm,Choi algorithm and Molecular markers,we compared the differences of their prognosies.Results ①)Kaplan-Meier univariate analysis of the clinical data of 147 DLBCL patients found that the 3-year overall survival (OS) rates were better in early stage (P=0.032),low IPI score (P=0.001),less than one extranodal involvement (P=0.014),and complete remission (P ＜ 0.01).The prognosies had no significant differenced in terms of gender,age,LDH,B symptoms and treatment options (P value ＞ 0.05).②For Hans model,GCB group had 42 cases,the ABC group 85 cases; GCB were 47 cases,ABC 80 cases (according to Choi model).Choi model suggested GCB subtype showed much better prognosis than ABC subtype (P=0.047),while Hans model shed no statistically significant difference (P=0.285).③Ki-67 of 75％ was found to significantly discriminate patients with good or bad prognosis.In R-CHOP group at the same time,low Ki-67 (P=0.017) and CD5-negative groups (P=0.012) were better.Cox proportional hazards regression model showed that IPI score (P=0.002) and Ki-67 (P=0.019) were independent adverse prognostic factors.Conclusion The Ann Arbor stage,IPI score,extranodal involvement status and Ki-67 were significantly associated with prognosis.Compared to Hans algorithm,Choi had an advantage to predict the differente prognosis between subtypes,and ABC group had poor outcome.Finally,both Ki-67 and IPI score were independent adverse prognostic factors.
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