Author(s): REN Pei-tu, FU Hong
Pages: 487-489
Year: 2013 Issue:  5
Journal: Chinese Journal of Surgery of Integrated Traditional and Western Medicine
Keyword:  p53; Cyclin E; immunohistochemistry; gallbladder carcinoma;
Abstract: Objective To explore the expression of p53 and Cyclin E in gallbladder carcinoma tissue and their significance. Methods The expression of p53 and Cyciln E in gallbladder carcinoma were detected by immunohistochemical technique and 50 cases of chronic cholecystitis tissues were collected as control. Results The positive expression rate of p53 and Cyclin E was higher in gallbladder carcinoma than that in chronic chole-cystitis tissues. It was also higher in mid-low differerentiated gallbladder carcinoma than that in high differerenti-ated tissues. The expression of p53 had no significant difference between the early stage gallbladder carcinoma (Nevin I and II) and advanced stage (Nevin III-V) in while Cyclin E had. The lymphatic metastasis was not relat-ed with the expression of p53 and Cyclin E. The 1-year survival rate was not related with the expression of p53, but it was higher in patients whose Cyclin E were negative than positive ones. Conclusion Analysis of expres-sion of p53 and Cyclin E is helpful to the early diagnosis and prognostic indication of gallbladder carcinoma.