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Recent progress in the development of novel anti-hepatitis B virus drugs
Author(s):
LIU Shi-zhu
,
SUN Dian-xing
Pages:
712
-
714
Year:
2013
Issue:
9
Journal:
Chinese Journal of Hepatology
Keyword:
Hepatitis B virus
;
Antiviral agents
;
Interferons
;
Abstract:
目前HBV感染仍是全球性的公共卫生问题,全世界有高达4亿的慢性HBV感染者,我国约占10%.干扰素(IFN)及核苷(酸)类似物[nucleos(t)ide analogue,NUCs]的抗病毒疗效在大多数地区已得到认可.在抗病毒治疗方面虽有重大突破,但现有治疗方法却很少能达到病毒清除的效果,IFN不良反应大,而NUCs疗程长,易耐药.所以探索新型抗病毒药物是乙型肝炎防治领域的一大热点.随着对HBV生活史的深入了解及HBV感染系统的建立,在新型抗病毒药物研制方面取得很大进展.
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