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Detection of SOD and MDA in lesions of guinea pig model with corticosteroid dependent dermatitis
Author(s): 
Pages: 483-484
Year: Issue:  8
Journal: World Clinical Drugs

Keyword:  corticosteroid dependent dermatitissuperoxide dismutase (SOD)malondialdehyde (MDA)adverse drug reaction;
Abstract: 目的 探讨激素依赖性皮炎豚鼠模型皮损处超氧化物歧化酶(SOD)和丙二醛(MDA)检测的意义.方法 将60只豚鼠随机分为模型组、阳性药物对照组和空白对照组,前两组分别予0.05%卤米松乳膏、单纯基质乳膏外涂45 d,空白对照组不给药,45 d后检测3组皮损中的SOD活性和MDA含量.结果 与阳性对照组和空白对照组比较,模型组豚鼠皮损处SOD水平明显降低,而MDA水平增高.结论 激素依赖性皮炎豚鼠模型皮损处SOD、MDA水平检测可为激素依赖性皮炎存在氧化失衡提供实验依据.
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