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ci ji su zhi liao dui jue jing fu nv wai zhou xue t lin ba xi bao de ying xiang
Author(s): 
Pages: 934-935,938
Year: Issue:  8
Journal: Modern Practical Medicine

Keyword:  雌激素T淋巴细胞细胞凋亡;
Abstract: 目的 探讨雌激素治疗对绝经妇女外周血T淋巴细胞的影响.方法 分离外周血T淋巴细胞,采用(Annexin V-FITC/PI双染色)测定淋巴细胞凋亡率,提取外周血淋巴细胞总RNA,RT-PCR法测定T淋巴细胞抗凋亡基因bcl-2及T淋巴细胞促进凋亡基因bax含量.结果 绝经组T淋巴细胞凋亡率高于生育年龄组(P<0.01).绝经+E组T淋巴细胞凋亡率低于绝经组(P<0.01).绝经组Bcl-2表达低于生育年龄组(P<0.01).绝经+E组Bcl-2表达高于绝经组(P<0.01).绝经组Bax表达高于生育年龄组(P<0.01);而绝经+E组Bax表达低于绝经组(P<0.01).结论 雌激素可以降低绝经妇女外周血T淋巴细胞的凋亡,主要机制可能是提高抗凋亡基因Bcl-2的表达和降低促凋亡基因Bax的表达水平.
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