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Comparison of effect of leflunomide and cydophosphamide on IgA nephropathy(Haas stage Ⅲ~ Ⅳ)
Author(s): 
Pages: 851-853
Year: Issue:  8
Journal: Modern Practical Medicine

Keyword:  肾小球肾炎IGA药物疗法来氟米特环磷酰胺;
Abstract: 目的 比较来氟米特和环磷酰胺分别联合小剂量糖皮质激素治疗IgA肾病(Haas分型Ⅲ~Ⅳ型)的疗效和安全性.方法 将90例IgA肾病(Haas分型Ⅲ~Ⅳ型)且激素治疗无效的患者分为来氟米特联合激素及环磷酰胺联合激素组,随访1年,治疗期间每月检测血常规、尿常规、24 h尿蛋白定量及肝肾功能等.结果 来氟米特组治疗缓解率(75.6%)与环磷酰胺组相当(73.3%,P> 0.05),但来氟米特组不良反应发生率(15.6%)低于环磷酰胺组(35.6%,P< 0.05).结论 来氟米特联合小剂量激素对激素治疗无效的IgA肾病(Haas分型Ⅲ~Ⅳ型)效果明显,且不良反应发生率低.
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