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Osteopontin in serum in patients with pemphigus
Author(s): 
Pages: 30-33
Year: Issue:  5
Journal: Guangzhou Medical Journal

Keyword:  天疱疮寻常型红斑型骨桥蛋白;
Abstract: 目的 探讨骨桥蛋白(osteopontin,OPN)与常见两型天疱疮的关系.方法 采用双抗体夹心酶联免疫吸附法(ELISA)检测寻常型天疱疮(pemphigus vulgaris,PV)患者30例、红斑型天疱疮(pemphigus erythematosus,PE)患者20例,以及健康对照组30例血清中OPN的水平.结果 PV组OPN血清浓度检测结果高于健康对照组,差异有统计学意义(P=0.000);也高于PE组OPN血清浓度,差异有统计学意义(P=0.000).而PE组OPN血清浓度检测结果与对照组比较差异无统计学意义(P>0.05).结论 与PE相比,PV的发生可能有更多细胞免疫参与其中,PV更应该警惕肿瘤的发生.
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