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Phospholipase A2 group ⅡA mRNA expression in human hepatocellular carcinoma and its clinical significance
Author(s): 
Pages: 829-831
Year: Issue:  4
Journal: Chinese Journal of Experimental Surgery

Keyword:  CarcinomahepatocellularPhospholipase A2Expression;
Abstract: Objective To investigate the correlations between hepatocellular carcinoma (HCC) and phospholipase A2 group ⅡA (PLA2G2A) mRNA expression level.Methods SYBR Green I real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) was used to detect PLA2G2A mRNA expression in 51 HCC tissues and their paired noncancerous liver tissues and 9 normal liver tissues.β-actin gene was used as an internal control and the relative expression level of PLA2G2A mRNA was analyzed using the method of 2-△△CT.The correlation between PLA2G2A mRNA levels in HCC tissues and clinicopathological features was analyzed.Results PLA2G2A mRNA levels in HCC tissues was 0.2446 times lower than that in their paired noncancerous liver tissues (P < 0.01) and 0.2339 times lower than that in normal liver tissues (P < 0.01).PLA2G2A mRNA was positively correlated with tumor differentiation (P < 0.05) and negatively with AFP level (P < 0.05) of HCC.PLA2G2A mRNA levels in HCC tissues underlying liver cirrhosis was higher than those without liver cirrhosis (P < 0.05).Conclusion The downregulation of PLA2G2A may get involved in the tumorgenesis and may be help for diagnosis of HCC.
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