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Expression of Ras homology C in cutaneous malignant melanoma and its relationship with clinical pathological features
Author(s): 
Pages: 855-857
Year: Issue:  4
Journal: Chinese Journal of Experimental Surgery

Keyword:  Cutaneous malignant melanomaRas homology CInvasionMetastasis;
Abstract: Objective To investigate the expression of Ras homology C (RhoC) mRNA and protein in cutaneous malignant melanoma and its relationship with clinical pathological features of cutaneous malignant melanoma.Methods The expression of RhoC mRNA and protein was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting in 32 cases of cutaneous malignant melanoma,as well as cutaneous junctional nevus and normal skin tissue were selected as controls.Results The expressions of RhoC mRNA and protein in cutaneous malignant melanoma were 0.468 ± 0.230 and 0.769 ± 0.411,which were higher than those in cutaneous junctional nevus and normal skin tissue (P <0.05).Furthermore,The expressions of RhoC mRNA and protein were 0.196 ± 0.042,0.411 ± 0.049,0.765 ±0.091 and 0.422 ±0.050,0.763 ±0.093,1.215 ±0.076 in the stage Ⅰ,Ⅱ,Ⅲand Ⅳof cutaneous malignant melanoma.The level of RhoC was correlated with increasing of clinical stage or the presence of lymphatic and distant metastases,however it was not correlated with age and gender.Conclusion Overexpression of RhoC,which as a molecular switch to control tumor metastasis,was associated with the carcinogenesis and progression of cutaneous malignant melanoma,and promoted invasion and metastasis in cutaneous malignant melanoma.
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