The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
Effect of the Combination Application of Salvia Miltiorrhiza and Diazepam on Anxiety in Mice
Author(s): 
Pages: 854-856
Year: Issue:  6
Journal: China Journal of Chinese Medicine

Keyword:  丹参地西泮抗焦虑谷氨酸酶联免疫法小鼠;
Abstract: 目的:探讨丹参、地西泮联合应用对小鼠的抗焦虑作用及其作用机制.方法:将雄性小鼠随机分成7组,分别为模型组,地西泮高、中、低剂量组,丹参地西泮高、中、低剂量组.模型组灌胃0.5% CMC-Na,其他组灌胃相应药物,连续给药5d.末次给药0.5h后,记录小鼠进入开臂的次数占总入臂次数的百分比(OE%)及在开臂中滞留的时间占总入臂时间的百分比(OT%).明暗箱实验记录小鼠10 min内在明暗箱中的穿箱次数.观察丹参、地西泮联合应用对小鼠焦虑的干预作用.用酶免法测定小鼠脑内γ-氨基丁酸,谷氨酸,5-羟色胺的含量.结果:丹参地西泮高剂量组能显著增加小鼠进入高架十字迷宫OE%、OT%,显示出对小鼠的抗焦虑作用.丹参地西泮中剂量组能显著增加小鼠进入高架十字迷宫OT%和小鼠明暗穿箱次数,二者联用有协同增效的趋势.结论:丹参、地西泮联合使用有增加抗焦虑作用的趋势,其抗焦虑机制可能与能降低小鼠脑内的GLu含量有关.
Related Articles
No related articles found