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Preventive Treatment of Unexplained Recurrent Spontaneous Abortion and Effect on Pregnancy Outcomes by Active Immunotherapy
Author(s): 
Pages: 876-878
Year: Issue:  6
Journal: China Journal of Chinese Medicine

Keyword:  复发性流产淋巴细胞主动免疫地屈孕酮片速效保胎灵片主动免疫疗法;
Abstract: 目的:探讨淋巴细胞主动免疫疗法对原因不明复发性流产的防治及妊娠结局的影响.方法:将900例原因不明复发性流产患者随机分为治疗组与西药对照组、中药对照组,每组各300例.治疗组给予淋巴细胞主动免疫治疗,西药对照组给予地屈孕酮片,每次10 mg,每日3次;中药对照组口服速效保胎灵片,每次3片,每日3次.结果:治疗后各组孕65 d及孕12周胎儿存活率分别为治疗组88.9%、84.2%,西药对照组58.3%、46.1%,中药对照组51.7%、40.1%,治疗组与两对照组比较,差异均有统计学意义(P<0.05);孕65d及孕12周流产率分别为治疗组11.1%、15.8%,西药对照组41.7%、53.9%,中药对照组48.2%、59.9%,治疗组与两对照组比较,差异均有统计学意义(P<0.05);治疗组IL-4及IL-6水平升高、IFN-γ及IL-2水平下降明显,与两对照组比较,差异均有统计学意义(P<0.05).结论:淋巴细胞主动免疫治疗可通过调节Thl型免疫应答向Th2型转换,增强原因不明复发性流产患者的免疫耐受,明显降低流产率,提高胎儿存活率,为原因不明复发性流产的有效治疗手段.
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