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Year:
Volume:
Issue:
Expression of Erythropoietin and Erythropoietin Receptor in Cell Lung Cancer
Author(s):
ZHANG Lianguo
,
XU Haitao
,
ZHANG Qingguang
,
GAO Xuejun
,
LIU Hongjian
,
LIU Jianwei
,
MA Yun
Pages:
169
-
171
Year:
2013
Issue:
3
Journal:
JOURNAL OF BINZHOU MEDICAL UNIVERSITY
Keyword:
促红细胞生成素
;
促红细胞生成素受体
;
肺癌
;
Abstract:
目的 探讨促红细胞生成素(EPO)和促红细胞生成素受体(EPO-R)在肺癌组织中的表达规律.方法 从接受根治性手术的患者获得肺癌组织,其中包括肺鳞状细胞癌12例,肺腺癌15例.采用免疫组化方法检测肺癌组织中EPO-R的表达情况;肺癌组织匀浆后,利用ELISA法检测肺癌组织中的EPO含量.结果 肺癌组织中EPO含量与肺癌患者的病理类型、组织分化程度及有无淋巴结转移无关(P>0.05).肺癌组织中EPO-R的表达高于癌周组织(P<0.05).结论 EPO进入肺癌组织中EPO可以与EPO-R结合参与肺癌的发生过程.
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