Author(s): ZHANG Ying-ying, WU Shu-huan, AN Jing-jun, LI Zhi-qin, ZHANG Hong-yu, YIN Hui
Pages: 48-50
Year: 2013 Issue:  10
Journal: Chinese Journal of Practical Medicine
Keyword:  Chronic hepatitis C; Pegylated interferon α-2a; Ordinary interferon α-2b; Rapid virological response; Early virological response;
Abstract: Objective To investigate the effect of interferon types and hepatitis C viral load on anti-viral treatment response of chronic hepatitis C.Methods The clinical data of 297 chronic hepatitis C who received antiviral treatment was studied,the correlation of response condition with interferon types and hepatitis C viral load was retrospectively analyzed.Results In HCV RNA above 105 IU/ml case,pegylated interferon α-2a received RVR was 74.7％,EVR was 81.6％,ordinary interferon α-2b received RVR was 58.7％,EVR was 62.5％.In HCV RNA below 105 IU/ml case,pegylated interferon α-2a received RVR was 80.9％,EVR was 88.2％,ordinary interferon α-2b received RVR was 80.6％,EVR was 85.5％.Conclusions When HCV RNA load was higher,pegylated interferon α-2a received higher rapid virological rate and early virological response than ordinary interferon α-2b.When HCV RNA load was lower,interferon type response to antiviral therapy was not statistically significant.