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Responses of afferent unit of the caudal nerve of diabetic hyperalgesic rats to sympathetic efferent stimulation
Author(s): 
Pages: 456-460
Year: Issue:  6
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  交感传出痛过敏单位放电糖尿病;
Abstract: 实验观察了刺激交感神经(sympathetic stimulation, SS)、静脉注射去甲肾上素(noradrenaline, NA)和酚妥拉明对糖尿病痛过敏大鼠尾神经中各种传入单位的影响.结果发现, 糖尿病痛过敏大鼠的具有自发放电的C单位和Aδ单位在SS后放电频率增加, α-受体阻断剂能消除这些自发放电活动; 在无自发放电的C单位和Aδ单位中, SS能使部分C单位和Aδ单位由静息状态转入活动状态;它虽不能诱发C-机械感受单位(C mechanical receptive unit, C-M)产生传入放电, 但可诱发部分C-机械热单位(C mechano-heat unit, C-MH)和C-多型单位(C polymodal unit, C-Pol)的活动; SS还能使部分Aδ-机械单位(Aδ mechanical receptive unit, Aδ-M)和Aδ-机械热单位(Aδ mechano-heat unit, Aδ-MH)产生传入放电; 它所诱发的C单位和Aδ单位反应的潜伏期不等, 但不短于5 s; SS不能引起糖尿病痛过敏大鼠Aβ机械感受性单位和对照组大鼠各类感受性单位产生新的传入活动.静脉注射NA可诱发糖尿病痛过敏大鼠的部分C单位和Aδ单位产生新的传入活动.结果提示, 交感神经末梢释放的NA对糖尿病痛过敏大鼠C单位和Aδ单位的兴奋作用是糖尿病大鼠产生痛过敏和感觉异常的外周因素.
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