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Increased cellular proliferation in BEL-7402 hepatoma cells transfected by human hepatic stimulator substance gene
Author(s): 
Pages: 473-477
Year: Issue:  6
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  肝刺激物质基因转染肝癌细胞增殖;
Abstract: 本文通过研究转染人肝刺激物质(hepatic stimulator substance, HSS)的肝癌细胞增殖状态, 进一步探讨了该基因的生物学功能.将人HSS基因导入BEL-7402肝癌细胞, 用Northern 和Southern杂交法证实该基因在靶细胞中有稳定表达.并通过测定细胞生长曲线、细胞S期比例和细胞MAPK活性, 观察到转HSS基因BEL-7402细胞增殖发生了改变.实验结果提示, HSS表达的肝癌细胞DNA合成增加、增殖速度加快, 可能与MAPK激活有关.HSS基因表达可促进细胞增殖.
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