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kang qian lie xian ai yao wu cu suan a bi te long de he cheng
Author(s): 
Pages: 1252-1254+1262
Year: Issue:  11
Journal: Chinese Journal of New Drugs

Keyword:  abiraterone acetateanti-prostate cancer drugsynthesis;
Abstract: 目的:优化抗前列腺癌药物醋酸阿比特龙的合成工艺。方法:以醋酸去氢表雄酮为起始原料经酯化、Suzuki偶联2步反应及柱色谱和重结晶两步纯化制得醋酸阿比特龙。结果:本工艺采用无机碱及DMAP减少了副产物的生成,革除了第一步的柱层析,降低了成本,简化了操作,并摸索重结晶溶剂,精制后的目标产物纯度99.89%,总收率45.1%。结论:本方法成本低,操作简单,收率高,适合工业化生产。
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