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bing zuo - zuo bing ji - - huan hu jing bao he wu de yan zhi
Author(s): 
Pages: 1337-1340
Year: Issue:  11
Journal: Chinese Journal of New Drugs

Keyword:  棓丙酯羟丙基-β环糊精包合物;
Abstract: 目的:研制棓丙酯-羟丙基-β-环糊精包合物,并考察其有关性质。方法:采用旋转蒸发法制备棓丙酯-羟丙基-β-环糊精包合物,用紫外分光光度法测定包合物中棓丙酯的含量、溶解度及溶出速度。采用紫外扫描、红外光谱、差示描量热及相溶解度法对棓丙酯、羟丙基-β-环糊精、棓丙酯-羟丙基-β-环糊精包合物、棓丙酯和羟丙基-β-环糊精的物理混合物进行物相鉴别。结果:羟丙基-β-环糊精与棓丙酯已形成包合物,包合物主客分子摩尔比为1∶1,包合物中药物的平均含量为(13.34±0.35)%。经包合后,棓丙酯的溶解度和溶出速度明显增大。结论:制备桔丙酯-羟丙基-β-环糊精包合物的工艺简单、易行,包合后可提高棓丙酯的溶解度和溶出速度。
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