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th17/treg xi bao shi heng yu zi gong jing ai
Author(s): 
Pages: 346-349
Year: Issue:  4
Journal: Chinese Bulletin of Life Sciences

Keyword:  Th17 /Treg cell imbalanceneoplasmscervical cancerhuman papilloma virus;
Abstract: Th17细胞是近年发现的一种新型CD4+效应性T细胞,以其特异性的分泌IL-17而命名。介导免疫耐受的Treg细胞和介导炎症反应的Th17细胞间功能和分化过程相互对抗,在正常状态下,两者保持平衡,但机体发生功能异常时常表现出Treg/Th17失衡,引起炎性反应、自身免疫性疾病、移植物抗宿主病等的发生和发展,并决定疾病的转归和预后,在肿瘤免疫中亦发挥了重要作用。该文就Treg/Th17失衡在肿瘤,尤其是子宫颈癌发生发展中的作用进行综述。
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