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thpok zai t xi bao fen hua fa yu zhong de zuo yong
Author(s): 
Pages: 340-345
Year: Issue:  4
Journal: Chinese Bulletin of Life Sciences

Keyword:  ThPOKCD4 + T cellCD8 + T cellGATA3Runx3iNKT cellγδT cell;
Abstract: ThPOK(T-helper-inducing POZ/Krueppel-like factor)又被称为Zbtb7b、Zfp67、cKrox,隶属于一个很大的转录因子家族——POK家族。ThPOK最初是被认为与Ⅰ型胶原蛋白基因的转录抑制有关,但近年来的研究发现,ThPOK在T细胞分化过程中至关重要,特别是对CD4+T细胞的分化发育起着命运决定的核心作用。该文综述了ThPOK在CD4+T细胞分化过程中的作用特点及其与另外两种重要转录因子GATA3和Runx3的相互作用关系,并在此基础上阐述了ThPOK在其他T细胞,如iNKT细胞、γδT细胞及效应CD8+T细胞中的作用功能。
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