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diao wang xiang guan ban dian yang dan bai de yan jiu jin zhan
Pages: 328-333
Year: Issue:  4
Journal: Chinese Bulletin of Life Sciences

Keyword:  ASCinflammationtumorapoptosisNF-κB;
Abstract: 凋亡相关斑点样蛋白(apoptosis-associated speck-like protein containing a CARD,ASC)是一种含有N端热蛋白样结构域和C端胱天氨酸募集结构域的接头分子。ASC可以通过它含有的同源蛋白互作结构域PYD和CARD的寡聚化来募集上下游与其含有同源结构域的其他蛋白,从而参与多条信号转导途径,在炎症反应、肿瘤发生、细胞凋亡和NF-κB信号通路的调节方面发挥重要的生物学作用。
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