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rong xue lin zhi dan jian zai que xue xing xin lv shi chang zhong de zuo yong
Author(s): 
Pages: 3-5
Year: Issue:  3
Journal: Chinese Heart Journal

Keyword:  溶血磷脂胆碱心肌缺血电生理;
Abstract: 用台氏液加溶血磷脂胆碱(LPC)3×10-4mol/L灌流离体绵羊心室小梁肌,其0期去极化最大速率(Vmax)、静息电位(RP)、动作电位幅值(APA)、动作电位复极达APA50%和APA90%的时程(APD50,APD90)分别下降39.8%,10.4%,14.5%,21.3%和14.8%(n=12,P<0.01);用“模拟缺血溶液”和LPC3×10-4mol/L灌流,其Vmax,RP,APA,APD50,APD90分别下降78.0%,22.7%,26.0%,35.4%和21.0%。实验中对“模拟缺血溶液”中各种成分对LPC效应的影响进行分析,发现其主要因素是酸中毒。结果表明:LPC是心肌缺血中心律失常的重要因素之一,缺血诱导的酸中毒更加重了LPC对心肌细胞的毒性作用
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