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fei yan ning fang dui fei ai gan xi bao wnt xin hao tong lu de ying xiang
Author(s): 
Pages: 77-82
Year: Issue:  6
Journal: Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai

Keyword:  "Feiyanning Decoction"lung cancer stem cellWnt signal pathwayβ-catenin;
Abstract: 目的:分离、鉴定肺癌干细胞,并探讨肺岩宁方对肺癌干细胞Wnt信号通路的干预作用。方法:分离、鉴定肺癌干细胞;将分离出的SP+肺癌干细胞分为对照组(空白血清+生理盐水)、单纯化疗(空白血清+DDP组)、肺岩宁方组(肺岩宁方含药血清+生理盐水)、综合治疗组(肺岩宁方含药血清+DDP),予体外药物干预后检测β-catenin蛋白表达及SP+肺癌干细胞凋亡情况。结果:分离的SP+、CD24+IGF-1R+、CD133+细胞具有肺癌干细胞特性,分离的β-catenin蛋白完整;综合治疗组诱导SP+干细胞凋亡优于其他组,各组凋亡率分别为综合治疗组79.2%、肺岩宁方组21.3%、DDP组33.7%、对照组0.3%。结论:本课题组已掌握分离、鉴定肺癌干细胞的技术,中药肺岩宁方联合化疗具有一定的诱导肺癌干细胞凋亡的作用。
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