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The study of oligoclonal/subclonal rearrangement of TCR gene in acute lymphoblastic leukemia with PCR-SSCP and it′s clinical significance
Author(s): 
Pages: 494-496
Year: Issue:  5
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  急性淋巴细胞白血病T细胞受体寡/亚克隆重排聚合酶链反应单链构象多态性;
Abstract: 目的为研究急性淋巴细胞白血病(ALL)TCR基因寡/亚克隆重排及与临床关系. 方法采用PCR-SSCP技术分析81例ALL TCR VγⅠ-Jγ基因重排. 结果 65例(80.2%)ALL病人存在TCR VγⅠ-Jγ基因重排,8例(8.6%)病人存在寡/亚克隆重排;寡/亚克隆ALL的白细胞计数显著高于非寡/亚克隆ALL(P<0.01);寡/亚克隆ALL的完全缓解率为37.5%,显著低于非寡/亚克隆ALL(80.7%)(P<0.005). 结论应用PCR-SSCP方法可确定ALL的寡/亚克隆性,ALL病人寡/亚克隆检测有助于预测疗效和预后判断.
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