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A study of HLA-DQA1*0301 and *0103 hereditary susceptibility between lacunar stroke and essential hypertension
Author(s): 
Pages: 497-500
Year: Issue:  5
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  腔隙性脑梗死高血压遗传易感性人类白细胞抗原-DQA1;
Abstract: 目的针对腔隙性脑梗死(lacunar stroke, LS)和原发性高血压(essential hypertension, EH)及多基因致病特点,进行 HLA-DQA1 位点的基因分型,分析其遗传易感性. 方法采用PCR-SSP方法对62例LS、52例EH和64例正常对照进行HLA-DQA1位点的基因分型. 结果① HLA-DQA1*0301等位基因与LS及EH呈显著正相关.② HLA-DQA1*0103等位基因与LS及EH呈显著负相关. 结论 HLA-DQA1*0301等位基因与LS及EH的发病有一定的关联,而HLA-DQA1*0103等位基因可能是LS及EH的保护性基因.
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