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zuo qing ju zuo dui bai wen yi wen c6 36 xi bao zhu de sha shang zuo yong ji dui qi xing tai ying xiang de yan jiu
Pages: 32-37
Year: Issue:  2
Journal: Acta Parasitology et Medica Entomologica Sinica

Keyword:  Deltamethrin Aedes albopictus C6/36 cell line Cytotoxic effects Morphological change;
Abstract: In this paper the MTT chromatometry method was employed for the studies of the cytotoxic effects and morphological changes of deltamethrin (DM) on Aedes albopictus C6/36 cell line and for observing the regeneration of C6/36 cell after DM treatment. The results showed that the LC 50 was 74.88μ g/ml after DM treatment of the C6/36 cell for 24h and the vital cells decreased with the increase of drug concentration. When DM concentration increased more than 20μ g/ml the morphological changes of the C6/36 cell monolayer occured as cell polymorphylism, spatium, scobinate, and granules in cytoplasm. With the increase of DM concentration, the cell lesion became more serious, showing cytoplasmic vacuole, chromatolysis as large granule and/or unorganized mass and the cell exfoliation, disintegration, eventually cell death. The regeneration of C6/36 cell damaged by high concentration of DM was relevant to the period of DM treatment, that is, with DM treatment for 24h, the cells slowly regenerated after a period of growth stasis, while the cells could not regenerate with DM treatment for 48h, but irreversible died instead.
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