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The pilot study of assessing blood perfusion assessment by contrast-enhanced ultrasound in liver fibrosis patients
Author(s): ZHANG Haiqing, WANG Xinghua, NIE Hongjuan, TU Jizheng, SHI Ying, LI Juan, LIANG Shufen
Pages: 146-
148,前插1
Year: 2013
Issue:
2
Journal: Chinese Imaging Journal of Integrated Traditional and Western Medicine
Keyword: 肝硬化; 血流动力学; 超声检查; 造影剂;
Abstract: 目的:探讨超声造影评价肝纤维化血流灌注特征的临床应用价值.方法:肝纤维化组15例,均经超声引导下肝组织活检病理证实,选取健康志愿者15例为正常对照组.所有研究对象经肘静脉团注对比剂SonoVue 2.4 ml,行实时灰阶超声造影检查,记录对比剂肝动脉到达时间(hepatic artery arrival time,HAAT)、门静脉到达时间(portal vein arrival time,PVAT)、肝静脉到达时间(hepatic vein arrival time,HVAT)及相应血管灌注强度参数(peak intensity,PI),同时计算肝动-静脉渡越时间(hepatic artery to hepatic vein transit time,HA-HVTT)、门静脉肝静脉渡越时间(portal vein to hepatic vein transit time,PV-HVTT)及门静脉-肝动脉间隔时间(PVAT-HAAT,VVT),分析2组间上述各参数差异有无统计学意义.结果:肝纤维化组PVAT较正常对照组缩短,差异有统计学意义(P<0.05),肝纤维化组HVAT、HA-HVTT、PV-HVTT及VVT较正常对照组缩短,差异均有统计学意义(P<0.01);2组HAAT、HA-PI、PV-PI及HV-PI差异均无统计学意义.结论:超声造影定量参数PVAT、HVAT及PV-H VTT可反映肝纤维化微循环及血流动力学改变,有望成为无创评价肝纤维化的定量指标.
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