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ruan jian hu gan pian de hu gan ji kang yi gan bing du zuo yong de shi yan yan jiu fu 74 li yi gan bing du xie dai zhe liao xiao guan cha
Author(s): 
Pages: 52-56
Year: Issue:  3
Journal: Research of Traditional Chinese Medicine

Keyword:  肝损伤乙肝病毒(HBsAgHBeAg)软坚护肝片;
Abstract: 通过软坚护肝片对能产生全部乙肝病毒指标细胞株的抑制试验和临床初步应用的结果,说明该药有抑制乙肝病毒HBeAg,HBsAg的作用,治疗指数(TI)分别为>5.74及>10.21(TI>2为有效)。临床应用的HBsAg转阴率为28%—57%,HBeAg转阴率达78%,动物实验结果表明:软坚护肝片有减轻CCl4及硫代乙酰胺所致小鼠急性肝损伤的作用,有减轻D—氨基半乳糖所致大鼠急性肝损伤的作用,其降低小鼠血清ALT活性的作用,并非通过直接抑制ALT而产生,对正常小鼠的血清ALT活动无明显影响。此外,尚有提高小鼠碳粒廓清能力及血清溶血素生成的作用。
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