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Effect of Bupleurum on collagen content in hepatic stellate cell media in vitro
Author(s): 
Pages: 502-503
Year: Issue:  4
Journal: JOURNAL OF TIANJIN MEDICAL UNIVERSITY

Keyword:  肝星状细胞肝纤维化柴胡;
Abstract: 目的:观察柴胡对肝星状细胞胶原蛋白分泌的影响.方法:体外培养肝星状细胞,选择48h细胞存活率>90%的药物浓度作为下述实验浓度,ELISA法检测细胞上清液中Ⅰ、Ⅲ、Ⅳ型胶原含量.结果:与对照组比较,柴胡组细胞上清液中Ⅰ、Ⅲ、Ⅳ型胶原含量明显降低(P<0.01).结论:柴胡可抑制肝星状细胞胶原蛋白的分泌,具有抗肝纤维化的作用.
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