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yan hu suo de yao li yan jiu . yan hu suo su yi he chou de nai yao xing
Author(s): 
Pages: 158-162
Year: Issue:  2
Journal: Acta Physiologica Sinica

Keyword:  延胡索素交叉耐药性非那酮大白鼠镇痛药物效能药物研究药理研究多雨千克;
Abstract: Alkaloids corydalis B and L,isolated from Corydalis ambigua Cham.et Sch. by Prof.T.Q.Chou,were found,in our previous report,to possess marked analgesic activity. However,their tolerance had not yet been investigated. The tolerance and cross tolerance to corydalis B and L in comparison with morphine are reported in this work.Experiments were made on rats by the thermal stimulation method.At first the subcutaneous dosages producing analgesia of approximately same duration were determined. Then a daily injection was administered to rats at the pre-determined dosages,and the change of pain sense.was measured.The results were as follows: (1)Tolerance of rats to analgesic action of corydalis B(50 mg/kg)or corydalis L(40 mg/kg)appeared after 11—13 days,and to that of morphine(3—3.5 mg/kg)after 6—8 days. (2)The phenomenon of cross tolerance between corydalis B,L and morphine had been observed in our experiment.
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