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Significance on expressions of Annexin-Ⅰ and its correlative gene proteins in endometrial hyperplasia, atypical hyperplasia and endometrial carcinoma
Author(s): 
Pages: 256-259
Year: Issue:  4
Journal: CHINESE JOURNAL OF PATHOLOGY

Keyword:  子宫内膜肿瘤钙磷脂结合蛋白Ⅰ受体erbB-2子宫内膜增生;
Abstract: 目的研究钙磷脂结合蛋白Ⅰ(Annexin-Ⅰ,AX-Ⅰ)在子宫内膜病变中的表达及在交界病变鉴别诊断中的意义.方法收集37份子宫内膜不同病变标本,经HE染色,在光镜下按国内及国际妇产科联合会(FIGO)标准分类,AX-Ⅰ、雌激素受体、孕激素受体、表皮生长因子受体、胰岛素样生长因子-Ⅰ受体与c-erbB-2的免疫组织化学染色采用LSAB法.结果腺囊性子宫内膜增殖症12例、子宫内膜不典型增生(ATH)10例、子宫内膜癌(EC)15例.免疫组织化学AX-Ⅰ在腺囊性增殖症中,除1例弱阳性外,均为阴性;在不典型增生组9例为强阳性,1例弱阳性;内膜癌则7例弱阳性,8例阴性;内膜鳞化或鳞癌区呈强阳性. c-erbB-2蛋白在不典型增生组9例为阳性,1例阴性.表皮生长因子受体(EGFR)均呈强阳性,胰岛素样生长因子受体-Ⅰ受体的表达弱且无规律.p53表达在EC组较ATH组略强.结论 AX-Ⅰ基因蛋白可能在肿瘤的发病初期起作用,癌变后其表达下降,甚至消失;AX-Ⅰ强阳性对ATH与EC鉴别具有一定价值. 另外,c-erbB-2与AX-Ⅰ的表达似乎存在一种平行的关系.
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