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Investigation of the clinicopathologic features, immunophenotype and Epstein-Barr virus infection of primary central nervous system lymphoma
Author(s): 
Pages: 264-267
Year: Issue:  4
Journal: CHINESE JOURNAL OF PATHOLOGY

Keyword:  中枢神经系统肿瘤淋巴瘤B细胞疱疹病毒4型;
Abstract: 目的观察原发性中枢神经系统淋巴瘤(PCNSL)的临床病理、免疫表型及其与EB病毒的关系.方法搜集25例PCNSL的临床资料并随访,应用单克隆抗体UCHL-1、L26、κ、λ、胶质纤维酸性蛋白(GFAP)和CS1-4行免疫组织化学染色,EB病毒寡核苷酸探针(EBER1/2)原位杂交,研究其免疫表型和EB病毒感染情况.结果 25例PCNSL均为B细胞淋巴瘤,EBER1/2原位杂交25例中仅2例(8%)出现阳性.结论本组PCNSL均为B细胞源性,且与EB病毒呈低相关性.
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