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zhi liao gao xue ya shu wu de yan jiu . guo chan ta zuo mu zhong shui rong xing sheng wu zuo de shu li zuo yong
Author(s): 
Pages: 54-63
Year: Issue:  1
Journal: Acta Physiologica Sinica

Keyword:  高血压离子交换剂小白鼠静脉注射全硷千克肾上腺素降压作用皮下注射反应系;
Abstract: The water-soluble total alkaloids, isolated from Chinese Rauwolfia verticillata (Lour.) Baill. with ion exchange resin (Zeo-Karb 226), were. prepared as HCl salts by Dr. C. T. Liu. The pharmacologic actions were as follows: (1) In mice the acute LD_(50) by subcutaneous, intraperitoneal, and oral routes were found to be 0.04, 0.01, and 0.6g/kg, resp. In rats, daily feeding at the dosage of 0.03g/kg/day for 12 weeks neither retarded their growths (Fig. 1)nor gave any pathologic change in the viscerae. (2) In anesthetized dongs and cats, intravenous injections of 1-3mg/kg produced a prompt fall of arterial blood pressure, lasting about 2-3 hours (Fig. 2). (3) Three Goldblatt hypertensive dogs were fed at the daily dosage of 10mg/kg for 4 weeks. There appeared a diastolic reduction of 10, 17, and 30mm Hg, respectively (Table 2), Shivering was observed in 2 out of the 3 dogs for nearly one week during the latter part of the medication periods. Their voluntary food intake, body weights, and the electrocardiogram did not show significant alterations. (4) The total alkaloids had no effect on the M-cholinergic reactive system. It inhibited the N-cholinergic reactive system, more active for the blocking of the ganglions than that of the myoneural junctions (Fig. 3). It also inhibited the adrenergic reactive system. Therefore the Itypotensive mechanism was mainly associated with ganglionic blocking and adrenolytic actions. Besides, there was an antagonism to the pressor responses, after carotid occlusion or elicited by electric stimulation of the central ends of vagus and sciatic nerves. (5) The total alkaloids had no effect on the convulsion and death in mice caused by strychnine, picrotoxin, pentylenetetrazol ("Metrazol"), nikethamide ("Coramine"), and nicotine (Table 3). It did not reduce the spontaneous activity nor antagonized the hyperactivity induced by caffeine (Fig. 4); it did not prolong the hexobarbital-sleeping time (Table 4). Hence it possessed no sedative effect.
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